circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: circCDR1as
Host Gene: CDR1
Genomic location(hg19): chrX:139865339-139866824:+
Genomic location(hg38): chrX:140783174-140784659:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

LNCaP; 22Rv1; PC-3; RWPE-1; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: XIAP, Ago2
Associated microRNA: miR-641
Biological function: Promotes proliferation, invasion and migration of prostate cancer cells.
Molecular mechanism: circCDR1as binds (sponges) miR-641, thereby relieving miR-641-mediated repression of XIAP and increasing XIAP expression.
Biological pathway or process:

proliferation (promotes); invasion (promotes); migration (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Wound Healing Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

circCDR1as may be a potential diagnostic marker for prostate cancer.
Description:

circCDR1as is up-regulated in prostate cancer cell lines and promotes PC-3 cell proliferation, invasion and migration. Mechanistically, circCDR1as binds miR-641 and modulates XIAP expression via a circCDR1as/miR-641/XIAP ceRNA axis.
Confidence score:

0.6253
Other information
Title:

Effect of the circCDR1as/miR-641/XIAP regulatory axis on the proliferation and invasion of the prostate cancer PC-3 cell line.

Journal: Oncology letters
Published: 2021
PubMed ID: 33907579
Study type:

biological research
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -