| Expression pattern: |
UP |
| Associated gene: |
SLC7A1 |
| Associated microRNA: |
miR-488-3p |
| Biological function: |
Promotes OS cell viability, migration, invasion, and OS progression. |
| Molecular mechanism: |
ceRNA mechanism; hsa_circ_0032462 sponges miR-488-3p and regulates SLC7A1 in OS. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0032462 expression is associated with lower overall survival and unfavorable prognosis; hsa_circ_0032462 is part of a combined diagnostic biomarker model with miR-488-3p and SLC7A1. |
| Description: |
hsa_circ_0032462 is up-regulated in osteosarcoma tissues and cells. It promotes OS cell viability, migration, invasion, and disease progression through a ceRNA axis involving miR-488-3p and SLC7A1, and high expression is associated with poor overall survival. |
| Confidence score: |
0.7624 |