| Expression pattern: |
UP |
| Associated gene: |
POU3F2, Argonaute2, Wnt/beta-catenin, c-myc |
| Associated microRNA: |
miR-924 |
| Biological function: |
promotes DDP resistance and malignant progression (viability, migration, invasion) and inhibits apoptosis in DDP-resistant HCC cells |
| Molecular mechanism: |
ceRNA sponge of miR-924 to upregulate POU3F2, thereby promoting cisplatin resistance and progression |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); Wnt/beta-catenin (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
circ_0031242 was higher in recurrent HCC patients after DDP-based chemotherapy than in primary (DDP-sensitive) patients, and proposed as a potential therapeutic target for chemoresistant HCC |
| Description: |
circ_0031242 (circ_PRMT5) is up-regulated in HCC, especially in DDP-resistant recurrent tumors and DDP-resistant cell lines. It promotes cisplatin resistance and malignant phenotypes by sponging miR-924 to increase POU3F2 expression, and its knockdown sensitizes xenografts to DDP. |
| Confidence score: |
0.6825 |