circRNA basic information
circBase ID: hsa_circ_0037128
Name: hsa_circ_NPRL3
Synonym: circ_0037128
Host Gene: hsa-miR-31-5p
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: cell line
Sample type details: human podocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-31-5p
Biological function: In HG-induced podocytes, hsa_circ_0037128 knockdown could alleviate HG-induced podocytes injury.
Molecular mechanism: hsa_circ_0037128 could sponge hsa-miR-31-5p to upregulate KLF9. hsa-miR-31-5p inhibitor could reverse the negative regulation of hsa_circ_0037128 silencing on HG-induced podocytes injury. Also, hsa-miR-31-5p relieved HG-induced podocytes injury, and this effect also could be reversed by KLF9 overexpression.
Survival: -
Supported No.:
 2
Description:

In summary, our data showed that hsa_circ_0037128 could promote HG-induced podocytes injury_ia_egulating miR-31-5p/KLF9 axis, showing that hsa_circ_0037128 might be a target for DN treatment.
Other information
Title:

Hsa_circ_0037128 aggravates high glucose-induced podocytes injury in diabetic nephropathy through mediating miR-31-5p/KLF9.

Journal: Autoimmunity
Published: 2022/3/15
PubMed ID: 35285770