circRNA basic information
circBase ID: hsa_circ_0000284
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung carcinoma
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung adenocarcinoma tissues; adjacent normal tissues
Cell lines:

HBE; A549; H1975; H1650
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes proliferation (based on colony formation data in H1975)
Molecular mechanism: unknown
Biological pathway or process:

proliferation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Colony Formation Assay
Clinical significance:

-
Description:

hsa_circ_0000284 is significantly upregulated in lung adenocarcinoma tissues and is strongly upregulated in lung cancer cell lines. Colony formation data suggest it affects proliferative capacity in H1975 cells, but no mechanism was characterized in this paper.
Confidence score:

0.4625
Other information
Title:

Circular RNA hsa_circ_0072309 promotes tumorigenesis and invasion by regulating the miR-607/FTO axis in non-small cell lung carcinoma.

Journal: Aging
Published: 2021
PubMed ID: 33879631
Study type:

combined biological and clinical study
Data availability: -
Code availability: -