| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential contributor to aggressive TNBC phenotype (e.g., migration/tumorigenesis-related programs) as an m6A-altered circRNA candidate biomarker. |
| Molecular mechanism: |
Subtype-specific m6A hypermethylation; suggested to influence post-transcriptional regulation (stability/translation) (not directly validated). |
| Biological pathway or process: |
migration (other); invasion (other); m6A modification (other) |
| Detected method: |
M
|
| Validation methods: |
MeRIP / MeRIP-seq; Microarray; RNase R Treatment; Bioinformatics Analysis |
| Clinical significance: |
Candidate subtype-specific m6A-modified circRNA biomarker for TNBC (differential methylation vs luminal). |
| Description: |
hsa_circRNA_057041 (circMETTL8) is reported as a TNBC-associated circRNA with increased m6A methylation (and discussed as upregulated in TNBC). The study positions it as a candidate biomarker linked to aggressive TNBC-associated biological programs, though without circRNA-specific functional experiments. |
| Confidence score: |
0.453 |