| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-21 |
| Biological function: |
Tumor suppressor in PCa by inhibiting proliferation and migration. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-21 to suppress PCa progression; downstream pathways inferred by GO/KEGG enrichment of miR-21 target genes. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); MAPK (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Cell Cycle Assay; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circSLC8A1 expression was associated with longer overall survival; circSLC8A1 expression displayed a positive correlation with clinical DFS. |
| Description: |
circSLC8A1 (hsa_circ_0000994) is down-regulated in prostate cancer tissues and cell lines and functions as a tumor suppressor. It inhibits PCa cell proliferation and migration by sponging miR-21, with downstream cancer-related pathways suggested by GO/KEGG enrichment (e.g., MAPK and chemokine signaling). High circSLC8A1 expression correlates with better patient survival. |
| Confidence score: |
0.7618 |