circRNA basic information
circBase ID: hsa_circ_0003204
Name: hsa_circ_USP36
Synonym: circ_0003204
Host Gene: USP36
Genomic location(hg19): chr17:76798405-76800060:-
Genomic location(hg38): chr17:78802323-78803978:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005311
MONDO name: atherosclerosis
Disease details: Atherosclerosis
Disease DO ID:
 1936
Disease MeSH ID:
 D050197
Disease NCIt ID:
 C35768
Disease ICD11 ID:
 109367356
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HUVECs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HDAC9, Ago2
Associated microRNA: miR-942-5p
Biological function: Aggravates ox-LDL-induced HUVEC injury by inhibiting cell viability/proliferation and promoting apoptosis, oxidative stress, and inflammation.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-942-5p to elevate HDAC9 expression (miR-942-5p targets HDAC9 3′UTR).
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes); inflammation (promotes); oxidative phosphorylation (unclear); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; ELISA; Western Blot
Clinical significance:

-
Description:

In an ox-LDL-stimulated HUVEC atherosclerosis cell model, circ_0003204 is up-regulated and exacerbates endothelial injury. Mechanistically, it sponges miR-942-5p, thereby relieving repression of HDAC9 and promoting apoptosis, oxidative stress, and inflammatory cytokine production while inhibiting cell growth/viability.
Confidence score:

0.5974
Other information
Title:

circ_0003204 Regulates Cell Growth, Oxidative Stress, and Inflammation in ox-LDL-Induced Vascular Endothelial Cells via Regulating miR-942-5p/HDAC9 Axis.

Journal: Frontiers in cardiovascular medicine
Published: 2021
PubMed ID: 33869307
Study type:

biological research
Data availability: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Code availability: -