circRNA basic information
circBase ID: hsa_circ_0050119
Name: hsa_circ_FKBP8
Synonym: circFKBP8
Host Gene: FKBP8
Genomic location(hg19): chr19:18648410-18649243:-
Genomic location(hg38): chr19:18537600-18538433:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002009
MONDO name: major depressive disorder
Disease details: major depressive disorder
Disease DO ID:
 1470
Disease MeSH ID:
 D003865
Disease NCIt ID:
 C35094
Disease ICD11 ID:
 -
Disease OMIM ID:
 608516
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole-blood samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: GPR68, PDXDC1, RNF213, NMT2, ABCC3
Associated microRNA: -
Biological function: Associated with depressive symptom severity and treatment response; may regulate neuroplasticity and involve in neuroinflammation in MDD.
Molecular mechanism: Predicted ceRNA network regulation of downstream mRNAs.
Biological pathway or process:

ceRNA regulation (other); immune regulation (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Cohort Study; Bioinformatics Analysis; In Vivo Animal Model
Clinical significance:

Potential peripheral biomarker for diagnosis of MDD; circFKBP8 change after rTMS predicted reduced HAMD-24 scores and may guide antidepressive treatment.
Description:

circFKBP8 (hsa_circ_0050119) is down-regulated in whole blood of MDD patients. Its expression is associated with serum BDNF and depressive symptom measures, and it increases after rTMS with changes predicting subsequent symptom improvement. Mechanistically, it was analyzed via a predicted ceRNA network linking to downstream mRNAs (e.g., GPR68, PDXDC1, RNF213, NMT2, ABCC3), suggesting roles in neuroplasticity/neuroinflammation.
Confidence score:

0.5849
Other information
Title:

Potential clinical value of circular RNAs as peripheral biomarkers for the diagnosis and treatment of major depressive disorder.

Journal: EBioMedicine
Published: 2021
PubMed ID: 33862583
Study type:

combined biological and clinical study
Data availability: PRJNA606351
Code availability: -