| Expression pattern: |
UP |
| Associated gene: |
AGO2, TCEB3, Ki-67, MMP-2, MMP-9 |
| Associated microRNA: |
miR-140-3p |
| Biological function: |
promotes proliferation and invasion; inhibits apoptosis (silencing shows opposite effects) |
| Molecular mechanism: |
acts as a miRNA sponge (ceRNA) for miR-140-3p to regulate TCEB3 |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ-0000212 is up-regulated in cervical cancer tissues and promotes malignant phenotypes. It functions as a ceRNA by sponging miR-140-3p, thereby relieving repression of TCEB3 and enhancing proliferation/invasion while reducing apoptosis in cervical cancer cells. |
| Confidence score: |
0.7045 |