circRNA basic information
circBase ID: hsa_circ_0091741
Name: -
Synonym: circ_0091741
Host Gene: -
Genomic location(hg19): chrX:152770078-152775004:+
Genomic location(hg38): chrX:153504620-153509546:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues
Cell lines:

GES-1; AGS; HGC-27; HGC-27/OXA; MKN-45; MKN-74; NCI-N87; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TRIM14, Dvl2, Wnt/beta-catenin signaling pathway, Ago2
Associated microRNA: miR-330-3p
Biological function: promotes gastric cancer cell autophagy, oxaliplatin resistance, cell viability, and tumorigenesis; inhibits apoptosis
Molecular mechanism: exosomal circ_0091741 acts as a ceRNA for miR-330-3p, increases TRIM14 expression, stabilizes Dvl2, activates the Wnt/beta-catenin signaling pathway, and thereby augments autophagy and oxaliplatin resistance
Biological pathway or process:

Wnt/beta-catenin (promotes); autophagy (promotes); drug resistance (promotes); chemoresistance (promotes); apoptosis (inhibits); proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; TUNEL; Western Blot; IF (Immunofluorescence); Co-IP; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry)
Clinical significance:

potential therapeutic target for gastric cancer treatment and chemoresistance
Description:

circ_0091741 is up-regulated in gastric cancer cells, oxaliplatin-resistant HGC-27/OXA cells, and gastric cancer cell-derived exosomes. Exosomal circ_0091741 promotes autophagy, oxaliplatin resistance, cell viability, and xenograft tumorigenesis by sponging miR-330-3p, increasing TRIM14, stabilizing Dvl2, and activating Wnt/beta-catenin signaling. Silencing exosomal circ_0091741 suppresses these malignant and chemoresistant phenotypes.
Confidence score:

0.7294
Other information
Title:

Exosomal circ_0091741 promotes gastric cancer cell autophagy and chemoresistance via the miR-330-3p/TRIM14/Dvl2/Wnt/beta-catenin axis.

Journal: Human cell
Published: 2023
PubMed ID: 36323918
Study type:

biological research
Data availability: GSE148334; Supplementary material available at https:// doi. org/ 10. 1007/ s13577-022-00790-6
Code availability: -