| Expression pattern: |
UP |
| Associated gene: |
PRRG4, REEP5, PSMB5, AGO2 |
| Associated microRNA: |
miR-1229 |
| Biological function: |
promotes proliferation and migration; inhibits apoptosis in ESCC cells |
| Molecular mechanism: |
ceRNA mechanism: circ_0000700 sponges miR-1229 to indirectly activate PRRG4, REEP5 and PSMB5 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa_circ_0000700 is up-regulated in ESCC cell lines and mainly localized in the cytoplasm. It promotes ESCC cell proliferation and migration and suppresses apoptosis by acting as a ceRNA sponge for miR-1229, thereby indirectly increasing PRRG4/REEP5/PSMB5 expression. |
| Confidence score: |
0.763 |