circRNA basic information
circBase ID: hsa_circ_0026939
Name: hsa_circ_ANKRD52
Synonym: circANKRD52
Host Gene: ANKRD52
Genomic location(hg19): chr12:56641276-56645879:-
Genomic location(hg38): chr12:56247492-56252095:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
684, 686
Disease MeSH ID:
D006528
Disease NCIt ID:
C3099
Disease ICD11 ID:
1294035808
Disease OMIM ID:
114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent normal tissues; normal liver tissues

Cell lines:

SMMC-7721; HepG2; SK-hep-1; Huh6; Huh7; LO2

In vivo animal model:

cell line-derived xenograft

circRNA-disease information
Expression pattern:
UN
Associated gene: BIRC5, Ago2
Associated microRNA: miR-497-5p
Biological function: promotes tumorigenesis, cell growth/proliferation and invasion
Molecular mechanism: Acts as a miR-497-5p sponge to upregulate BIRC5 expression (ceRNA-like regulation).
Biological pathway or process:

proliferation (promotes); invasion (promotes); ceRNA regulation (promotes)

Detected method:
Q
H
Validation methods:

RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); circRIP; RNA Pull-Down; Actinomycin D / DRB Stability Assay; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Western Blot; Clinical Sample Validation

Clinical significance:

might predict poor survival in early-stage HCC

Description:

In HCC, circANKRD52 (hsa_circ_0026939) functions as an oncogenic circRNA that promotes proliferation and invasion. It predominantly localizes to the cytoplasm and sponges miR-497-5p, thereby relieving repression of BIRC5 and enhancing tumorigenesis in vitro and in a cell line-derived xenograft model.

Confidence score:

0.8294

Other information
Title:

CircANKRD52 Promotes the Tumorigenesis of Hepatocellular Carcinoma by Sponging miR-497-5p and Upregulating BIRC5 Expression.

Journal: Cell transplantation
Published: 2021
PubMed ID: 33845641
Study type:

combined biological and clinical study

Data availability: TCGA (http://xena.ucsc.edu/); GSE17548
Code availability: -