| Expression pattern: |
UP |
| Associated gene: |
ABCC1 |
| Associated microRNA: |
miR‐361‐3p |
| Biological function: |
promotes cell growth, invasion and migration; promotes cisplatin (DDP) resistance; inhibits apoptosis |
| Molecular mechanism: |
circ_0058357 acts as a miRNA sponge for miR-361-3p to regulate ABCC1 expression, thereby affecting DDP resistance and malignant phenotypes in DDP-resistant NSCLC cells |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; Luciferase Reporter Assay; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_0058357 is up-regulated in cisplatin (DDP)-resistant NSCLC tissues and resistant cell lines. It promotes malignant phenotypes and DDP resistance by sponging miR-361-3p to de-repress ABCC1, thereby enhancing ABCC1 expression and reducing DDP sensitivity. |
| Confidence score: |
0.786 |