| Expression pattern: |
UP |
| Associated gene: |
ZEB2 |
| Associated microRNA: |
miR-1270 |
| Biological function: |
Promotes cervical cancer cell proliferation, migration, invasion and metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0001247 functions as a ceRNA by sponging miR-1270, thereby up-regulating ZEB2 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; BrdU; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay |
| Clinical significance: |
Provides a new basis for the diagnosis and treatment of cervical cancer. |
| Description: |
circ_0001247/hsa_circ_0001247 is up-regulated in cervical cancer tissues and cell lines. It promotes cervical cancer cell proliferation, migration, invasion and metastasis while inhibiting apoptosis, mainly by sponging miR-1270 to increase ZEB2 expression. The study suggests circ_0001247 may have value as a diagnostic or therapeutic basis in cervical cancer. |
| Confidence score: |
0.6829 |