| Expression pattern: |
UP |
| Associated gene: |
S100P, Ago2 |
| Associated microRNA: |
miR-671 |
| Biological function: |
promotes proliferation, invasion, EMT and tumor growth; enhances CSC properties |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-671 to relieve repression of S100P, inducing EMT and activating AKT signaling |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); invasion (promotes); PI3K/AKT (promotes); ceRNA regulation (promotes); stemness (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Transwell Assay; Colony Formation Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
High circ_0092314 expression is associated with poorer overall survival and disease-free survival in PAAD patients. |
| Description: |
circ_0092314 is up-regulated in PAAD tissues/cells and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation, invasion and EMT by sponging miR-671 to de-repress S100P, leading to activation of AKT signaling; high expression is associated with worse patient survival. |
| Confidence score: |
0.8034 |