circRNA basic information
circBase ID: hsa_circ_0077753
Name: hsa_circ_GJA1
Synonym: -
Host Gene: GJA1
Genomic location(hg19): chr6:121756744-121770873:+
Genomic location(hg38): chr6:121435598-121449727:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HMT-3522 S1 (S1); Cx43-KO-S1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: Cx43
Associated microRNA: -
Biological function: -
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR
Clinical significance:

-
Description:

hsa_circ_0077753 is a GJA1 (Cx43) derived circRNA isoform significantly down-regulated upon Cx43 silencing in the S1 3D culture model. The study did not establish a specific miRNA sponging axis or clinical association for this isoform.
Confidence score:

0.1155
Other information
Title:

A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation.

Journal: Scientific reports
Published: 2021
PubMed ID: 33514777
Study type:

biological research
Data availability: Geobrowser (to be assigned a number when published)
Code availability: -