circRNA basic information
circBase ID: hsa_circ_0007961
Name: hsa_circ_SPRED2
Synonym: -
Host Gene: SPRED2
Genomic location(hg19): chr2:65559120-65572030:-
Genomic location(hg38): chr2:65331986-65344896:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HMT-3522 S1 (S1); Cx43-KO-S1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-99a-3p, miR-653-5p, miR-600, miR-511-5p
Biological function: Not validated as a risk-assessment axis; proposed circRNA-miRNA axis did not show expected inverse dysregulation and was not supported in the patient cohort.
Molecular mechanism: Predicted miRNA sponging (ceRNA), but axis not validated.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0007961 (from SPRED2) is significantly up-regulated upon Cx43 silencing in the S1/Cx43-KO-S1 3D risk-progression model. It was proposed to sponge several miRNAs, but the predicted inverse circRNA-miRNA pattern and patient-cohort support were lacking, so the axis was not validated for breast cancer initiation risk assessment.
Confidence score:

0.5135
Other information
Title:

A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation.

Journal: Scientific reports
Published: 2021
PubMed ID: 33514777
Study type:

combined biological and clinical study
Data availability: Geobrowser (to be assigned a number when published)
Code availability: -