| Expression pattern: |
UP |
| Associated gene: |
SDC1 |
| Associated microRNA: |
miR-515-5p, miR-1246 |
| Biological function: |
Promotes bladder cancer cell proliferation, migration, invasion and colony formation; inhibits apoptosis; promotes xenograft tumor growth. |
| Molecular mechanism: |
Acts as a molecular sponge for miR-515-5p to positively regulate SDC1 expression (ceRNA-like mechanism). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Bioinformatics Analysis; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model; Microarray |
| Clinical significance: |
The aberrant expression of circCEP128 in bladder cancer tissues and cells indicates potential diagnostic value. |
| Description: |
circCEP128 is up-regulated in bladder cancer tissues and cell lines and promotes malignant phenotypes. Mechanistically, it binds (sponges) miR-515-5p to relieve repression of SDC1, thereby enhancing proliferation/migration/invasion and inhibiting apoptosis; circCEP128 knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.742 |