circRNA basic information
circBase ID: hsa_circ_0078607
Name: hsa_circ_SLC22A3
Synonym: circ_0078607
Host Gene: SLC22A3
Genomic location(hg19): chr6:160819010-160831878:+
Genomic location(hg38): chr6:160397978-160410846:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005211
MONDO name: ovarian serous adenocarcinoma
Disease details: high-grade serous ovarian cancer
Disease DO ID:
 0050933, 5744
Disease MeSH ID:
 -
Disease NCIt ID:
 C7550
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

HGSOC tissues; adjacent non-cancerous tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: Fas
Associated microRNA: miR-518a-5p
Biological function: Associated with poor prognosis; low expression linked to advanced FIGO stage and higher serum CA125; (prior work cited) inhibits proliferation and invasion and promotes apoptosis.
Molecular mechanism: This study establishes prognostic association; no new mechanism experimentally investigated. (Background/prior work cited) circ_0078607 may act as a miRNA sponge for miR-518a-5p to elevate Fas expression.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis
Clinical significance:

Low circ_0078607 expression predicts shorter PFS and OS and is an adverse prognostic indicator in HGSOC.
Description:

In 49 paired clinical samples, circ_0078607 is down-regulated in HGSOC tumor tissues versus adjacent non-cancerous tissues. Low circ_0078607 expression is associated with advanced FIGO stage, higher CA125, and shorter PFS/OS, and is an independent adverse prognostic factor in HGSOC.
Confidence score:

0.4758
Other information
Title:

Low Expression of Circular RNA hsa_circ_0078607 Predicts Poor Prognosis in High-Grade Serous Ovarian Cancer.

Journal: Cancer management and research
Published: 2021
PubMed ID: 33833570
Study type:

clinical study
Data availability: -
Code availability: -