circRNA basic information
circBase ID: hsa_circ_0126897
Name: hsa_circ_SLC4A4
Synonym: -
Host Gene: SLC4A4
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissue; adjacent tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: SLC4A4
Associated microRNA: -
Biological function: unknown
Molecular mechanism: Predicted circRNA/miRNA interaction network; associated with decreased expression of SLC4A4 in CRC tissues.
Biological pathway or process:

cell cycle (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential biomarker for CRC.
Description:

hsa_circ_0126897_CBC1 is significantly down-regulated in CRC tissues versus adjacent tissues and is proposed as a potential CRC biomarker. The study builds a predicted circRNA/miRNA network in which it is the top hub and reports decreased expression of its reported target gene SLC4A4, with broader enrichment pointing to cell-cycle-related processes.
Confidence score:

0.5135
Other information
Title:

Screening potential biomarkers for colorectal cancer based on circular RNA chips.

Journal: Oncology reports
Published: 2018
PubMed ID: 29658599
Study type:

combined biological and clinical study
Data availability: The datasets used during the present study are available from the corresponding author upon reasonable request.
Code availability: -