circRNA basic information
circBase ID: -
Name: hsa_circ_NFIX
Synonym: circNFIX
Host Gene: NFIX
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004996
MONDO name: childhood acute myeloid leukemia
Disease details: pediatric acute myeloid leukemia
Disease DO ID:
 0070323
Disease MeSH ID:
 -
Disease NCIt ID:
 C9160
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

diagnosis pediatric AMLs
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Higher expression was significantly associated with inferior EFS and OS; prior functional evidence cited in discussion suggested silencing circNFIX inhibits AML cell proliferation and promotes apoptosis.
Molecular mechanism: Not mechanistically tested in this study; association with proliferation and apoptosis was discussed based on consistency with prior work.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits)
Detected method:
S
Validation methods:

RNA-seq; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Higher circNFIX expression was significantly associated with inferior EFS and OS in AML.
Description:

circNFIX was identified in the study as a prognostic circRNA whose higher expression was associated with inferior EFS and OS in AML. The article connected this observation to prior functional reports that circNFIX may promote proliferation and inhibit apoptosis.
Confidence score:

0.348
Other information
Title:

circRNAs as prognostic markers in pediatric acute myeloid leukemia.

Journal: Cancer letters
Published: 2024
PubMed ID: 38621457
Study type:

bioinformatics study; clinical study
Data availability: HRA000789
Code availability: -