| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-630 |
| Biological function: |
Suppresses GC cell proliferation/tumor cell growth. |
| Molecular mechanism: |
Direct binding to miR-630 (miRNA sponge-like interaction), negatively regulating miR-630; miR-630 mimics reverse the anti-proliferative effect of circRNA_100269. |
| Biological pathway or process: |
proliferation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Lower circRNA_100269 in tumor (negative group) is associated with worse overall survival; expression correlates with histological subtypes and node invasion number. |
| Description: |
circRNA_100269 is down-regulated in gastric cancer tissues and GC cell lines. It directly interacts with miR-630, negatively correlates with miR-630 in tissues, and its overexpression inhibits GC cell proliferation; this anti-proliferative effect is reversed by miR-630 mimics. |
| Confidence score: |
0.7544 |