| Expression pattern: |
UP |
| Associated gene: |
MAPRE1 |
| Associated microRNA: |
miR-3194-3p |
| Biological function: |
Promotes NSCLC proliferation, invasion and migration; inhibits apoptosis; promotes tumor growth; promotes cisplatin resistance and reduces cisplatin sensitivity. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-3194-3p to up-regulate MAPRE1, thereby promoting malignant behaviors and cisplatin resistance in NSCLC. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
Serum circSOX13 was elevated in NSCLC patients and may be a potential diagnostic marker; higher circSOX13 levels were associated with TNM stage and lymph node metastasis. |
| Description: |
circSOX13 is up-regulated in NSCLC tissues and patient serum and promotes malignant phenotypes and cisplatin resistance. Mechanistically, circSOX13 sponges miR-3194-3p to up-regulate MAPRE1, enhancing proliferation/migration/invasion and inhibiting apoptosis. circSOX13 knockdown suppresses tumor growth and increases cisplatin sensitivity in a xenograft model. |
| Confidence score: |
0.713 |