circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circ_USP9Y-TTTY15
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

prostate cancer tissue samples
Cell lines:

LNCaP
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: TTTY15, USP9Y
Associated microRNA: -
Biological function: Validated as a read-through circRNA (rt-circRNA) circular molecule spanning two adjacent genes (TTTY15 and USP9Y).
Molecular mechanism: Read-through circularization (rt-circRNA) involving two adjacent genes; circular junction validated by RNase R resistance and Sanger sequencing.
Biological pathway or process:

other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR
Clinical significance:

-
Description:

A read-through circRNA spanning adjacent genes TTTY15 and USP9Y was experimentally validated in LNCaP cells. Divergent-primer RT-qPCR, RNase R resistance, and Sanger sequencing confirmed the backspliced junction and circular nature of this rt-circRNA detected in prostate cancer tissue samples.
Confidence score:

0.4358
Other information
Title:

The Landscape of Circular RNA in Cancer.

Journal: Cell
Published: 2019
PubMed ID: 30735636
Study type:

biological research
Data availability: https://mioncocirc.github.io/; https://mioncocirc.github.io/download/
Code availability: https://github.com/mcieslik-mctp/codac