circRNA basic information
circBase ID: hsa_circ_0007456
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr17:11984672-12016677:+
Genomic location(hg38): chr17:12081355-12113360:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue; adjacent non-tumor tissue
Cell lines:

HEK-293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: CDCA8, KPNA2, PRC1, TOP2A
Associated microRNA: hsa-miR-139-5p
Biological function: May act as a miRNA sponge for hsa-miR-139-5p in a macrophage-infiltration-related regulatory network in HCC.
Molecular mechanism: miRNA sponge interaction with hsa-miR-139-5p supported by luciferase reporter assay (binding site dependent).
Biological pathway or process:

ceRNA regulation (other); immune regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection
Clinical significance:

-
Description:

This study identifies hsa_circ_0007456 as a hub circRNA in a macrophage-infiltration-related circRNA-miRNA-mRNA network in HCC. It directly binds hsa-miR-139-5p in a binding-site-dependent luciferase reporter assay, supporting a miRNA-sponge (ceRNA) mechanism potentially affecting the miR-139-5p-CDCA8/KPNA2/PRC1/TOP2A subnetwork.
Confidence score:

0.4375
Other information
Title:

Construction and analysis of macrophage infiltration related circRNA-miRNA-mRNA regulatory networks in hepatocellular carcinoma.

Journal: PeerJ
Published: 2020
PubMed ID: 33150086
Study type:

combined biological and clinical study
Data availability: The raw measurements are available in the Supplemental Files.
Code availability: -