| Expression pattern: |
DS |
| Associated gene: |
HNRNPA2B1, SOD1, B2M, RPL27, EIF3D, PDCD6IP, MIF, NUP93, CDC42 |
| Associated microRNA: |
hsa-miR-142-3p, hsa-miR-205-5p, hsa-miR-21-5p, hsa-miR-320a |
| Biological function: |
Associated with AD traits (DE/Braak/CDR) and acts as a hub node in the circRNA-miRNA-mRNA network connecting to inflammation/viral-response mRNAs. |
| Molecular mechanism: |
circRNA-miRNA-mRNA interaction network based on ENCORI AGO-CLIP-seq interactions; circRTN4 connects with multiple miRNAs and downstream mRNAs in IL-12 response/viral process-enriched clusters. |
| Biological pathway or process: |
inflammation (other); immune regulation (other); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circRTN4 is a hub circRNA in the shared AD-cancer circRNA-miRNA-mRNA network. It connects to miRNAs including hsa-miR-142-3p, hsa-miR-205-5p, hsa-miR-21-5p and hsa-miR-320a, linking to mRNAs enriched for IL-12 response and viral-process/inflammation-related functions. |
| Confidence score: |
0.1768 |