| Expression pattern: |
DS |
| Associated gene: |
HNRNPA2B1, SOD1, B2M, RPL27, EIF3D, PDCD6IP, MIF, NUP93, CDC42 |
| Associated microRNA: |
hsa-miR-205-5p, hsa-miR-155-5p, hsa-miR-142-3p, hsa-miR-21-5p, hsa-miR-320a |
| Biological function: |
Associated with AD diagnosis/clinical severity and shows inverse expression-pattern correlation between AD and some cancers; identified as a hub node in the circRNA-miRNA-mRNA network linked to inflammation/viral-response genes. |
| Molecular mechanism: |
circRNA-miRNA-mRNA interaction network (CLIP-seq-supported miRNA binding) connecting circPICALM with miRNAs (e.g., hsa-miR-155-5p, hsa-miR-205-5p) and downstream mRNAs enriched for IL-12 response and viral process. |
| Biological pathway or process: |
inflammation (other); immune regulation (other); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circPICALM is one of the hub circRNAs in a CLIP-informed circRNA-miRNA-mRNA network shared between AD-associated circRNA changes and multiple cancers. It connects to miRNAs such as hsa-miR-155-5p and hsa-miR-205-5p and to inflammation/viral-response-related mRNAs, supporting a potential inflammation-linked cross-disease mechanism. |
| Confidence score: |
0.1768 |