| Expression pattern: |
UP |
| Associated gene: |
AR, SOCS2-AS1, Ago2 |
| Associated microRNA: |
miR-599 |
| Biological function: |
Promotes glioma cell proliferation, migration, invasion, and aggressiveness. |
| Molecular mechanism: |
Acts as a miR-599 sponge to relieve miR-599-mediated suppression of AR, and AR activates SOCS2-AS1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Upregulation of circ-ASPH in tissue samples was associated with lower overall survival rate for patients with GM after surgery. |
| Description: |
circ-ASPH (hsa_circRNA_104634), derived from ASPH, is upregulated in glioma tissues/cells and its high expression correlates with worse overall survival. Functionally, it promotes proliferation, migration and invasion of glioma cells by sponging miR-599 to relieve repression of AR and consequently increasing SOCS2-AS1 expression. |
| Confidence score: |
0.8554 |