circRNA basic information
circBase ID: hsa_circ_0001666
Name: hsa_circ_FAM120B
Synonym: hsa_circ_000742
Host Gene: FAM120B
Genomic location(hg19): chr6:170626457-170639638:+
Genomic location(hg38): chr6:170317369-170330550:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues; xenograft tumor tissues
Cell lines:

TPC-1; IHH-4; GLAG-66; Nthy-ori 3-1; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ETV4, AGO2
Associated microRNA: miR-330-5p, miR-193a-5p, miR-326
Biological function: promotes PTC cell proliferation and tumor growth; inhibits apoptosis; promotes G1/S phase transition
Molecular mechanism: acts as a miRNA sponge for miR-330-5p, miR-193a-5p and miR-326 to upregulate ETV4 (ceRNA-like regulation)
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; FISH / smFISH; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; Bioinformatics Analysis; Microarray
Clinical significance:

Its expression was associated with lymph node metastasis of patients with PTC.
Description:

hsa_circ_0001666 is up-regulated in papillary thyroid carcinoma tissues and cell lines and is associated with lymph node metastasis. It promotes PTC proliferation and tumor growth and suppresses apoptosis by sponging miR-330-5p/miR-193a-5p/miR-326 to upregulate ETV4.
Confidence score:

0.8635
Other information
Title:

Circular RNA hsa_circ_0001666 sponges miR‑330‑5p, miR‑193a‑5p and miR‑326, and promotes papillary thyroid carcinoma progression via upregulation of ETV4.

Journal: Oncology reports
Published: 2021
PubMed ID: 33760216
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.
Code availability: -