| Expression pattern: |
DN |
| Associated gene: |
HDAC1, Ago2 |
| Associated microRNA: |
miR-135b-5p |
| Biological function: |
promotes proliferation, inhibits apoptosis, and inhibits inflammation in ox-LDL-treated HUVECs |
| Molecular mechanism: |
circRSF1 acts as a miRNA sponge for miR-135b-5p to modulate HDAC1 expression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); inflammation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Annexin V/PI Flow Cytometry; ELISA; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Bioinformatics Analysis |
| Clinical significance: |
providing new perspectives and methods for the treatment and diagnosis of AS |
| Description: |
circRSF1 (hsa_circ_0000345), derived from RSF1 and mainly localized in the cytoplasm, is down-regulated in ox-LDL-treated HUVECs (an in vitro atherosclerosis model). Functionally, circRSF1 overexpression restores proliferation and suppresses apoptosis and inflammatory responses by sponging miR-135b-5p, thereby relieving miR-135b-5p-mediated repression of HDAC1. |
| Confidence score: |
0.7812 |