circRNA basic information
circBase ID: hsa_circ_0007006
Name: hsa_circ_DYM
Synonym: -
Host Gene: DYM
Genomic location(hg19): chr18:46783379-46808545:-
Genomic location(hg38): chr18:49257009-49282175:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001509
MONDO name: endocrine exophthalmos
Disease details: thyroid-associated ophthalmopathy / TAO
Disease DO ID:
 12359
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

orbital connective tissue; orbital fat tissues
Cell lines:

orbital fibroblasts / OFs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: COL1A1, MMP2, relaxin signaling pathway
Associated microRNA: -
Biological function: may regulate fibrosis-related genes (COL1A1, MMP2) and affect TAO typing
Molecular mechanism: ceRNA network; negative correlation with COL1A1 and MMP2; relaxin signaling pathway involvement
Biological pathway or process:

relaxin signaling (other); fibrosis (inhibits); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Western Blot
Clinical significance:

hsa_circ_0007006 could represent a meaningful diagnostic and prognostic biomarker for TAO subtyping
Description:

hsa_circ_0007006 is down-regulated in type II TAO versus type I TAO. In orbital fibroblasts, its lentiviral overexpression decreases COL1A1 and MMP2 protein levels, and the study links this axis to relaxin signaling and fibrosis-related TAO subtyping.
Confidence score:

0.5623
Other information
Title:

Differential Circular RNA Expression Profiling of Orbital Connective Tissue From Patients With Type I and Type II Thyroid-Associated Ophthalmopathy.

Journal: Investigative ophthalmology & visual science
Published: 2022
PubMed ID: 36409215
Study type:

combined biological and clinical study
Data availability: -
Code availability: -