| Expression pattern: |
DN |
| Associated gene: |
BATF2, AGO2 |
| Associated microRNA: |
miR-942-5p |
| Biological function: |
Inhibits colony-forming ability, migration and invasion, and promotes apoptosis of CRC cells; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-942-5p to upregulate BATF2. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Western Blot; Clinical Sample Validation |
| Clinical significance: |
Decreased expression of circ_0005927 was closely correlated with tumor size (≥5 cm), tumor (T) stage (T1+T2) and lymphatic node (N) metastasis (N0). |
| Description: |
circ_0005927 is down-regulated in colorectal cancer tissues/cells and functions as a tumor suppressor. It sponges miR-942-5p to relieve repression of BATF2, thereby inhibiting colony formation, migration and invasion, promoting apoptosis, and suppressing xenograft tumor growth. |
| Confidence score: |
0.7795 |