| Expression pattern: |
UP |
| Associated gene: |
TRIM37, Ago2 |
| Associated microRNA: |
miR-1236-3p |
| Biological function: |
Promotes cervical cancer cell proliferation, cell cycle progression, and cell migration; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1236-3p, thereby relieving repression of TRIM37. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (other); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; EdU Staining; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circRNA_101996 expression is associated with advanced stage, lymph node metastasis, larger tumor size, and lower overall survival rate in cervical cancer patients. |
| Description: |
circRNA_101996 is up-regulated in cervical cancer tissues and cell lines and promotes proliferation, cell-cycle progression, migration, and tumor growth. Mechanistically, it sponges miR-1236-3p to de-repress TRIM37, forming the circRNA_101996/miR-1236-3p/TRIM37 axis; high circRNA_101996 correlates with worse overall survival. |
| Confidence score: |
0.8428 |