circRNA basic information
circBase ID: hsa_circ_0000053
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:36826821-36828257:-
Genomic location(hg38): chr1:36361220-36362656:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HOXA5
Associated microRNA: miR-196a-5p, miR-196b-5p
Biological function: May play an important role in bone metastasis of Xuanwei lung adenocarcinoma via a ceRNA network.
Molecular mechanism: ceRNA mechanism (circRNA acts as a miRNA sponge) involving miR-196a-5p/miR-196b-5p to regulate HOXA5.
Biological pathway or process:

ceRNA regulation (other); metastasis (promotes)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

This study reports that hsa_circ_0000053 is up-regulated in Xuanwei lung adenocarcinoma bone metastasis and may function as a ceRNA. It is proposed to sponge miR-196a-5p/miR-196b-5p and thereby affect HOXA5 within a circRNA/miRNA/mRNA regulatory network relevant to bone metastasis.
Confidence score:

0.5466
Other information
Title:

Transcriptome Sequencing reveals the expressed profiles of mRNA and ncRNAs and regulate network via ceRNA mediated molecular mechanism of lung adenocarcinoma bone metastasis in Xuanwei.

Journal: Translational cancer research
Published: 2021
PubMed ID: 35116241
Study type:

combined biological and clinical study
Data availability: http://dx.doi.org/10.21037/tcr-20-2376
Code availability: -