| Expression pattern: |
UP |
| Associated gene: |
MUC1, Ago2 |
| Associated microRNA: |
miR-485-5p |
| Biological function: |
Promotes HCC cell proliferation, migration and invasion, and inhibits apoptosis; facilitates HCC progression. |
| Molecular mechanism: |
Acts as a competing endogenous RNA (ceRNA) sponge for miR-485-5p, indirectly up-regulating MUC1. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circHECTD1 is up-regulated in HCC tissues and promotes malignant phenotypes of HepG2 cells. It functions as a ceRNA by sponging miR-485-5p, thereby relieving repression of MUC1 and facilitating proliferation, migration/invasion, and anti-apoptosis effects. |
| Confidence score: |
0.7032 |