circRNA basic information
circBase ID: hsa_circ_0077837
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr6:131247744-131277639:-
Genomic location(hg38): chr6:130926604-130956499:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tumors; adjacent normal tissues; LUAD tissues; LUSC tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May act as a tumor suppressor during NSCLC tumorigenesis and serves as a diagnostic biomarker for NSCLC.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis
Clinical significance:

ROC curve analysis supports diagnostic potential to discriminate NSCLC from normal tissues (AUC 0.921).
Description:

hsa_circ_0077837 is down-regulated in both LUAD and LUSC tumor tissues compared with adjacent normal tissues. It shows strong diagnostic performance for distinguishing NSCLC tumors from normal tissues by ROC analysis.
Confidence score:

0.6605
Other information
Title:

RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.

Journal: Molecular cancer
Published: 2019
PubMed ID: 31484581
Study type:

combined biological and clinical study
Data availability: All the data obtained and/or analyzed during the current study were available from the corresponding authors on reasonable request.
Code availability: -