circRNA basic information
circBase ID: hsa_circ_0009034
Name: hsa_circ_MAP3K5
Synonym: -
Host Gene: MAP3K5
Genomic location(hg19): chr6:136990420-137019820:-
Genomic location(hg38): chr6:136669282-136698682:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: Osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor specimen
Cell lines:

143B; MG63; hFOB1.19
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May serve as a diagnostic biomarker for osteosarcoma (reported downregulated in OSA cell lines).
Molecular mechanism: Included as a node in a circRNA-miRNA-mRNA ceRNA network (specific miRNA/mRNA axis not reported for this individual circRNA).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR
Clinical significance:

May be a promising diagnostic biomarker for OSA.
Description:

hsa_circ_0009034 (host gene MAP3K5) is downregulated in osteosarcoma cell lines versus osteoblast controls and was incorporated into a circRNA-miRNA-mRNA ceRNA network. The study suggests it may have diagnostic biomarker potential for OSA, but does not experimentally validate a specific miRNA/mRNA regulatory axis for this circRNA.
Confidence score:

0.1904
Other information
Title:

Circular RNA-Related CeRNA Network and Prognostic Signature for Patients with Osteosarcoma.

Journal: Cancer management and research
Published: 2021
PubMed ID: 34629900
Study type:

combined biological and clinical study
Data availability: GSE33382; GSE65071; GSE96964; TARGET (phs000468)
Code availability: -