| Expression pattern: |
UP |
| Associated gene: |
EGFR |
| Associated microRNA: |
miR-7 |
| Biological function: |
Promotes proliferation, migration, and invasion of PTC cells; suppresses apoptosis; facilitates EMT. |
| Molecular mechanism: |
Acts as a miR-7 sponge to upregulate EGFR (ceRNA-like mechanism), promoting PTC progression; EMT changes may contribute to migration/invasion. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
Upregulation of ciRS-7 is closely associated with poor prognoses; ciRS-7 may be a prognostic biomarker and therapeutic target in PTC. |
| Description: |
ciRS-7 is up-regulated in papillary thyroid cancer tissues and cell lines. Functionally, it promotes PTC cell proliferation, migration and invasion (partly via EMT) by sponging miR-7 and thereby increasing EGFR expression. |
| Confidence score: |
0.713 |