circRNA basic information
circBase ID: hsa_circ_0074371
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr5:142434003-142437312:+
Genomic location(hg38): chr5:143054438-143057747:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: SIRPA
Associated microRNA: hsa-miR-145-5p
Biological function: -
Molecular mechanism: ceRNA mechanism
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0074371 is down-regulated in AML and was highlighted as a key circRNA in the circRNA-miRNA-hub gene subnetwork, predicted to regulate SIRPA by sponging hsa-miR-145-5p.
Confidence score:

0.1768
Other information
Title:

The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.

Journal: BMC cancer
Published: 2021
PubMed ID: 33722210
Study type:

bioinformatics study
Data availability: GSE116617; GSE94591; GSE142699; GSE114868
Code availability: -