circRNA basic information
circBase ID: -
Name: hsa_circ_KIAA0907
Synonym: -
Host Gene: KIAA0907
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OSCC cancer tissues; adjacent normal tissues; tumor
Cell lines:

HSC6; OECM1; HOK
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: UNC13C
Associated microRNA: miR-96-5p
Biological function: inhibits migration and invasion; inhibits glycolysis; promotes apoptosis; increases radiosensitivity; suppresses tumor growth
Molecular mechanism: ceRNA sponging of miR-96-5p to regulate UNC13C expression
Biological pathway or process:

migration (inhibits); invasion (inhibits); glycolysis (inhibits); apoptosis (promotes); radioresistance (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Transfection; Transwell Assay; Annexin V/PI Flow Cytometry; Colony Formation Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

Circ-KIAA0907 is down-regulated in OSCC tissues and cell lines and mainly localizes to the cytoplasm. Functionally, its overexpression suppresses migration, invasion, glycolysis, and tumor growth while promoting apoptosis and radiosensitivity. Mechanistically, it acts as a ceRNA that sponges miR-96-5p to upregulate UNC13C.
Confidence score:

0.7977
Other information
Title:

Circ-KIAA0907 inhibits the progression of oral squamous cell carcinoma by regulating the miR-96-5p/UNC13C axis.

Journal: World journal of surgical oncology
Published: 2021
PubMed ID: 33715625
Study type:

combined biological and clinical study
Data availability: -
Code availability: -