circRNA basic information
circBase ID: hsa_circ_0068682
Name: hsa_circ_DLG1
Synonym: circRNA_57
Host Gene: DLG1
Genomic location(hg19): chr3:196778447-196867135:-
Genomic location(hg38): chr3:197051576-197140264:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005016
MONDO name: diabetic kidney disease
Disease details: diabetic nephropathy
Disease DO ID:
 -
Disease MeSH ID:
 D003928
Disease NCIt ID:
 C84417
Disease ICD11 ID:
 615062102
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HK2 / HK-2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: ceRNA network construction (predicted)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

Exosomal circRNA_57 (DLG1-derived; circBase IDs hsa_circ_0068682/hsa_circ_0008583) is down-regulated in exosomes from high-glucose-treated HK-2 cells versus controls. The study reports RNA-seq-based differential expression and predicted ceRNA/network analyses, but no direct functional experiments validating its role in diabetic nephropathy.
Confidence score:

0.1768
Other information
Title:

Determining the influence of high glucose on exosomal lncRNAs, mRNAs, circRNAs and miRNAs derived from human renal tubular epithelial cells.

Journal: Aging
Published: 2021
PubMed ID: 33714195
Study type:

biological research
Data availability: -
Code availability: -