| Expression pattern: |
UP |
| Associated gene: |
IGF2BP3, DNM1L |
| Associated microRNA: |
- |
| Biological function: |
Promotes HCC cell proliferation, migration, invasion, tumor growth and metastasis; inhibits apoptosis; promotes mitochondrial fission. |
| Molecular mechanism: |
circ_0098823 binds the RBP IGF2BP3 and enhances DNM1L mRNA stability/expression, thereby promoting mitochondrial fission and HCC invasion and metastasis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); mitochondrial function (promotes); mRNA stability (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ_0098823 may have diagnostic value for HCC; ROC AUC was 0.98. |
| Description: |
circ_0098823 is an ERBB3-derived circRNA that is up-regulated in HCC tissues and HGF-induced HCC cell lines. It promotes HCC cell viability, migration, invasion, tumor growth and metastasis while suppressing apoptosis, at least partly by binding IGF2BP3 to stabilize DNM1L mRNA and enhance mitochondrial fission. Its expression also showed diagnostic potential for distinguishing HCC from normal controls. |
| Confidence score: |
0.8711 |