circRNA basic information
circBase ID: hsa_circ_0028717
Name: hsa_circ_GCN1
Synonym: circRNA_164
Host Gene: GCN1
Genomic location(hg19): chr12:120568988-120615358:-
Genomic location(hg38): chr12:120131184-120177555:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005016
MONDO name: diabetic kidney disease
Disease details: diabetic nephropathy
Disease DO ID:
 -
Disease MeSH ID:
 D003928
Disease NCIt ID:
 C84417
Disease ICD11 ID:
 615062102
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HK2 / HK-2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: ceRNA network construction (predicted)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

Exosomal circRNA_164 (GCN1-derived; circBase IDs hsa_circ_0028717/hsa_circ_0000448) is down-regulated in exosomes from high-glucose-treated HK-2 cells versus controls, suggesting potential involvement in diabetic nephropathy-related changes. Its functional role is not experimentally validated and is only explored via RNA-seq and predicted ceRNA/network analyses.
Confidence score:

0.1768
Other information
Title:

Determining the influence of high glucose on exosomal lncRNAs, mRNAs, circRNAs and miRNAs derived from human renal tubular epithelial cells.

Journal: Aging
Published: 2021
PubMed ID: 33714195
Study type:

biological research
Data availability: -
Code availability: -