circRNA basic information
circBase ID: hsa_circ_0007456
Name: hsa_circ_MAP2K4
Synonym: circMAP2K4
Host Gene: MAP2K4
Genomic location(hg19): chr17:11984672-12016677:+
Genomic location(hg38): chr17:12081355-12113360:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

Huh7; Hep3B; MHCC97H; HCCLM3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: YTHDF1
Associated microRNA: hsa-miR-139-5p
Biological function: Promotes HCC cell proliferation.
Molecular mechanism: Acts as a miRNA sponge for hsa-miR-139-5p, relieving repression of YTHDF1 and increasing YTHDF1 expression.
Biological pathway or process:

proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Western Blot
Clinical significance:

-
Description:

circMAP2K4 (hsa_circ_0007456) promotes proliferation of hepatocellular carcinoma cells. Mechanistically, it sponges hsa-miR-139-5p, leading to increased YTHDF1 expression and partial reversal of miR-139-5p-mediated growth inhibition.
Confidence score:

0.6575
Other information
Title:

Analysis and Validation of circRNA-miRNA Network in Regulating m6A RNA Methylation Modulators Reveals CircMAP2K4/miR-139-5p/YTHDF1 Axis Involving the Proliferation of Hepatocellular Carcinoma.

Journal: Frontiers in oncology
Published: 2021
PubMed ID: 33708621
Study type:

combined biological and clinical study
Data availability: TCGA; ICGC; GSE31384; GSE94508; GSE97332; GSE78520
Code availability: -