| Expression pattern: |
UP |
| Associated gene: |
IFIT1, IFIT3, CXCL11, IL-1beta, IL-17, Vimentin, Twist |
| Associated microRNA: |
miR-4756 / hsa-miR-4756-5p |
| Biological function: |
promotes HCC cell migration and tumor metastasis; increases IL-1beta and IL-17 levels |
| Molecular mechanism: |
ceRNA mechanism: circUBAP2 sponges miR-4756 to counteract miR-4756-mediated inhibition of IFIT1/IFIT3, promoting downstream inflammatory cytokines and migration/metastasis |
| Biological pathway or process: |
migration (promotes); metastasis (promotes); inflammation (promotes); ceRNA regulation (promotes); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; Transfection; Transwell Assay; Wound Healing Assay; ELISA; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
circUBAP2 expression was higher in metastatic HCC tissues than nonmetastatic HCC tissues and para-carcinoma tissues |
| Description: |
In HCC, CXCL11 from CAFs induces upregulation of circUBAP2. circUBAP2 promotes HCC cell migration and metastasis by sponging miR-4756, thereby relieving miR-4756 repression of IFIT1/IFIT3 and increasing IL-1beta/IL-17-associated inflammatory output. |
| Confidence score: |
0.7373 |