circRNA basic information
circBase ID: hsa_circ_0102272
Name: hsa_circ_RTN1
Synonym: circRTN1
Host Gene: hsa-miR-101-3p
 
 
 
Disease basic information
DO ID:
 1781
DO name: thyroid gland cancer
Disease details: thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: PTC cell lines (TPC-1, IHH-4), control cell line (Nthy-ori 3-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: hsa-miR-101-3p
Biological function: Silencing of circRTN1 suppressed PTC cell proliferation, migration, and invasion in vitro
Molecular mechanism: circRTN1/hsa-miR-101-3p/HMGB1 axis, miRNA sponge
Survival: -
Supported No.:
 3
Description:

CircRTN1 depletion impeded PTC cell malignancy via the miR-101-3p/HMGB1 pathway, which provided a possible circRNA-targeted therapeutic strategy for PTC.
Other information
Title:

CircRTN1 stimulates HMGB1 to regulate the malignant progression of papillary thyroid cancer by sponging miR-101-3p.

Journal: Hormones (Athens)
Published: 2023/2/25
PubMed ID: 36826778