| Expression pattern: |
UP |
| Associated gene: |
SCAP |
| Associated microRNA: |
- |
| Biological function: |
Associated with immune imbalance and immune-related pathways in thymoma; hypothesized to affect parental gene instability (SCAP). |
| Molecular mechanism: |
Predicted ceRNA mechanism via downstream miRNAs-mRNA; possible host-gene-related effect (hypothesis). |
| Biological pathway or process: |
MAPK (other); inflammation (other); immune regulation (other); apoptosis (other); PI3K/AKT (other); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RNase R Treatment; RT-qPCR; divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
Potential biomarker; parental gene SCAP high expression associated with better overall survival in thymoma (circRNA itself not directly analyzed for survival). |
| Description: |
hsa_circ_0007291 is up-regulated in thymoma and was used to build predicted circRNA-miRNA-mRNA networks linked to immune-related pathways (e.g., MAPK/TNF). The study also analyzed its host gene SCAP in Kaplan-Meier plots, suggesting clinical relevance at the parental-gene level. |
| Confidence score: |
0.6556 |