| Expression pattern: |
DN |
| Associated gene: |
FOXO3, AGO2 |
| Associated microRNA: |
miR-155 |
| Biological function: |
Inhibits proliferation, migration and invasion and promotes apoptosis in NSCLC cells (tumor-suppressive role). |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-155 to upregulate linear FOXO3 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); Transfection; MTT; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circRNA-FOXO3 shows diagnostic value for NSCLC (AUC 0.782; sensitivity 80.0%; specificity 73.3%). |
| Description: |
circRNA-FOXO3 is down-regulated in NSCLC tissues and cell lines and acts as a tumor suppressor. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-155 to increase linear FOXO3 expression, thereby inhibiting proliferation/migration/invasion and promoting apoptosis. It also shows diagnostic potential based on ROC analysis. |
| Confidence score: |
0.795 |