| Expression pattern: |
UN |
| Associated gene: |
STAT3, GPX4, SLC7A11 |
| Associated microRNA: |
miR-106a-5p |
| Biological function: |
promotes proliferation, invasion and migration; inhibits apoptosis; inhibits ferroptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
circRHOT1 sponges miR-106a-5p, thereby regulating STAT3 and attenuating ferroptosis and malignant progression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ferroptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circRHOT1 promotes malignant progression of breast cancer cells (proliferation, invasion/migration) and suppresses apoptosis and ferroptosis. Mechanistically, it functions as a ceRNA by sponging miR-106a-5p to upregulate STAT3, and its knockdown suppresses tumor growth in a cell line-derived xenograft model. |
| Confidence score: |
0.5637 |