circRNA basic information
circBase ID: -
Name: hsa_circ_CTNNA1
Synonym: circCTNNA1
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005178
MONDO name: osteoarthritis
Disease details: osteoarthritis
Disease DO ID:
 8398
Disease MeSH ID:
 D010003
Disease NCIt ID:
 C3293
Disease ICD11 ID:
 558562409
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

synovial fluid samples
Cell lines:

synoviocytes (type B, primary cells)
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-29a
Biological function: CircCTNNA1 suppresses LPS-induced apoptosis of type B synoviocytes in osteoarthritis.
Molecular mechanism: CircCTNNA1 directly interacts with and may sponge miR-29a, reducing the pro-apoptotic effect of miR-29a without regulating miR-29a expression.
Biological pathway or process:

apoptosis (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; RNA Pull-Down; Transfection; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

CircCTNNA1 expression levels in OA patients were closely correlated with OA stages.
Description:

This study reports that circCTNNA1 is significantly downregulated in synovial fluid from patients with osteoarthritis. Functionally, circCTNNA1 directly interacts with miR-29a and suppresses LPS-induced apoptosis of type B synoviocytes, suggesting a protective role in OA-related synoviocyte injury.
Confidence score:

0.6369
Other information
Title:

Circular RNA circCTNNA1 is downregulated in osteoarthritis and sponges miR-29a to suppress LPS-induced apoptosis of synoviocytes.

Journal: Immunopharmacology and immunotoxicology
Published: 2022
PubMed ID: 34751080
Study type:

combined biological and clinical study
Data availability: -
Code availability: -