| Expression pattern: |
UP |
| Associated gene: |
USP11 |
| Associated microRNA: |
miR-132-3p |
| Biological function: |
promotes cell growth, migration and invasion; inhibits apoptosis; promotes xenograft tumor growth |
| Molecular mechanism: |
circ_DOCK1 acts as a miRNA sponge for miR-132-3p to regulate USP11 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Colony Formation Assay; EdU Staining; MTT; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_DOCK1 (hsa_circ_0020397) is up-regulated in colorectal cancer and mainly localized in the cytoplasm. It promotes proliferation and metastasis and inhibits apoptosis by sponging miR-132-3p to increase USP11 expression, and its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.8326 |