| Expression pattern: |
UP |
| Associated gene: |
EN2 |
| Associated microRNA: |
miR-382-5p |
| Biological function: |
Promotes colorectal cancer cell multiplication (proliferation), migration, invasion, and EMT. |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-382-5p, thereby up-regulating EN2. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circ_0000467 overexpression was positively related to tumor size, histological grade, and TNM stage in CRC patients. |
| Description: |
circ_0000467 is up-regulated in colorectal cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes CRC cell proliferation, migration, invasion and EMT by sponging miR-382-5p and thereby increasing EN2 expression. |
| Confidence score: |
0.7589 |