| Expression pattern: |
UP |
| Associated gene: |
AKT1 |
| Associated microRNA: |
miR-637 |
| Biological function: |
Promotes GC cell proliferation, viability, migration, and invasion in vitro. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-637, thereby relieving repression of AKT1. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; Luciferase Reporter Assay; CCK8; Transwell Assay; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circHIPK3 might serve as a potential biomarker for GC. |
| Description: |
circHIPK3 is up-regulated in gastric cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes gastric cancer cell viability/proliferation, migration, and invasion by functioning as a ceRNA that sponges miR-637 and thereby increases AKT1 expression. |
| Confidence score: |
0.6676 |