circRNA basic information
circBase ID: hsa_circ_0001498
Name: -
Synonym: circ_0001498
Host Gene: -
Genomic location(hg19): chr5:76758919-76760634:-
Genomic location(hg38): chr5:77463094-77464809:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

Huh7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: TGFBRAP1
Associated microRNA: miR122
Biological function: might be associated with promoting the HCC progression
Molecular mechanism: Predicted circRNA-miRNA-mRNA signaling axis (circ_0001498-miR122-TGFBRAP1) associated with HCV core expression.
Biological pathway or process:

ceRNA regulation (other); proliferation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

In HCV core-expressing Huh7 cells (an HCV-related HCC context), the study proposes a circ_0001498/miR122/TGFBRAP1 signaling axis that may contribute to carcinogenic progression. The axis is based on prediction platform analysis and is presented as a possible mechanism associated with promoting HCC progression.
Confidence score:

0.348
Other information
Title:

Hepatitis C virus core impacts expression of miR122 and miR204 involved in carcinogenic progression via regulation of TGFBRAP1 and HOTTIP expression.

Journal: OncoTargets and therapy
Published: 2018
PubMed ID: 29535540
Study type:

combined biological and clinical study
Data availability: -
Code availability: -